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Dr. Rhonda Patrick on Health · ViralLoop

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Dr. Rhonda Patrick@foundmyfitness

Vigorous exercise might be the perfect thing to start doing when taking a break from alcohol. A hormone that is released both by muscle and the liver during exercise is FGF21. Giving FGF21 — as a drug, reduced alcohol consumption by up to 50% in alcoholic mice & vervet monkeys.

1.9K likes33 repliesPosted Oct 5, 2022

View the original on X Written by Dr. Rhonda Patrick. Captured Sep 4, 2026.

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Hook: Plain observation
Structure: Hook → Landing
Style: Conversational paragraphs at a steady pace.
Tone: plain, matter-of-fact
Written for: Founders, marketers and operators

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one dozen rats at a keyboard

It’s embarrassing but the Jimmy Kimmel debacle actually is important. It was the first real attempt by the Project 2025 movement to flex their muscle against someone who wasn’t a nameless, defenseless nobody and it catastrophically flopped in less than a week.

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Horse Nomad (Chicago-style) ⚔️

Famously, human learning takes *very little* energy. A toddler learns thousands of words and an entire grammar while eating nothing but raspberries, before learning to read. An LLM needs a nuclear reactor and the entire internet as a training corpus.

First recovery in the ByBit hack. ~$43m (15,000 cmETH) has been clawed back from the hacker. I saw the recovery possibility soon after the hack and SEAL connected me with Mantle/mETH team who made it happen. Huge shoutout to SEAL, Mantle, and mETH teams for their quick action.

As shocking as the Kimi K3 release. Massive performance gain was just with post-training Model is 3x smaller than GLM 5.2 (10x smaller than K3) & works on a MacBook / Spark This is Q1 flagship (Opus 4.6/GPT 5.4) level for < $0.28/m tokens (100x cheaper)

Together with SpaceXAI, we’re training a significantly larger model from scratch, using 10x more total compute. With Colossus 2’s million H100-equivalents and our combined data and training techniques, we expect this to be a major leap in model capability.

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In last week's newsletter, I talked about how resistance training can support cardiovascular health in postmenopausal women. It's not just aerobic exercise! You can now read the issue - and sign up for free - in our archive. We send it out every week. t.co

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Creatine is a supplement most women should be taking, especially post-menopause. 5 grams/day combined with resistance exercise increases lean mass and muscle strength but has inconsistent effects on bone mineral density. It makes productive training slightly more productive.

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Five servings of fruits and vegetables per day may not be enough for heart health benefits. Only 20% of people who meet these guidelines have an estimated flavanol intake of 500 mg/day, a level associated with lower cardiovascular disease risk in randomized controlled studies.

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This podcast is definitely going to be part of my regular listening queue. Congrats on the launch @mackinprof and @gibalam! Both are previous guests on the FoundMyFitness pod. I've learned so much from both.

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I'd encourage everyone to grab a copy of Dr. Arthur Brooks' new book 'The Meaning of Your Life' or gift it to someone who might enjoy it (I plan to buy a few copies myself!) He shares so much wisdom on how to live a happy, fulfilling life.

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Incredibly interesting result here. Combining rapamycin with exercise didn't help and may have even impaired exercise adaptations in older adults! Reminds me of metformin (also once marketed as a "longevity drug"), which also blunts exercise adaptations in certain contexts.