Jacob Trefethen on AI

Jacob Trefethen@JacobTref

I'm joining the OpenAI Foundation to lead the Life Sciences & Curing Diseases program. We're starting with three areas of grantmaking: * AI for Alzheimer's * Public Data for Health * Accelerating Progress on High-Mortality and High-Burden Diseases Time to get to work!

1.1K likes95 repliesPosted Mar 24, 2026

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Viral score

Based on absolute engagement — the platform doesn’t expose follower counts here, so large accounts score higher.

From likes, comments.

Why it worked

Opens with a short, self-contained line that is easy to take in at a glance.
Uses short lines and white space, which makes a long post feel quick to read.
Follows a clear Hook → Context → List → Landing shape, so the reader always knows where they are.
Ends on a short line that is easy to quote and repeat.
Written from experience rather than as advice, which is harder to argue with.
Short enough to read in full without expanding, which removes a step before the point lands.

The mechanics

Hook: Announcement
Structure: Hook → Context → List → Landing
Style: Short lines with heavy white space, built to be scanned.
Tone: personal, energetic, punchy
Written for: People building with AI

Analysis by ViralLoop — not written by the original author.

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